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High Protein Nutrition Shake with Pea Protein and a Mixed Fiber Blend Enhances Prebiotic Impact in an in vitro Colon Model

Authors: Erin C. Lamb1, Vanessa Millovich1, Peter Azmi2, Jonas Ghyselinck2, Christina J. Valentine1

Research Presented as a Poster at the 2026 Annual Scientific Conference for The American Society for Nutrition (ASN)

Population and Design

  • Mechanistic study to assess how organic pea protein-based High Protein Nutrition Shake (HPNS) impact gut microbial activity from fecal samples of healthy adults (n=10). Study tested this formula in a preclinical model that mimics digestion and gut microbiota fermentation.

Outcomes Measured

  • Gut microbiota composition, microbial metabolic activity (pH, gas production, and short chain fatty acids), levels of by-products or waste (branched chain fatty acids and ammonia). All results were compared against the negative control.

Results

  • Organic pea protein-based HPNS enriched microbial communities associated with short chain fatty metabolism in fecal samples from healthy adults.

  • Organic pea protein-based HPNS significantly increased production of acetate, propionate, and butyrate.

  • Untargeted metabolic fingerprinting showed significant differences in metabolite signatures for the organic pea protein-based HPNS compared with the control samples.

Affiliations:

1. Kate Farms, Goleta, CA, United States

2. ProDigest, Gent, Belgium

Citation:

Lamb EC et al., 2026; Curr Dev Nutr, 10(2026): 109085